Slavin A A, Etingov E D, Bezborodko I G, Pyshnyĭ S P
Antibiotiki. 1977 Aug;22(8):689-93.
It was shown that "nepheline coagulant"--Al2 (SO4)3-18H2O was effective in coagulating the admixtures in oleandomycin fermentation broth. The use of the "nepheline coagulant" in an amount of 1 to 3 per cent (by the weight) of the volume of the oleandomycin fermentation broth provided butyl acetate extraction of the antibiotic without formation of stable emulsion. Addition of the "nepheline coagulant" in an amount of 1 to 2 per cent (by the weight) to the fermentation broth markedly increased the rate of the fermentation broth filtration.
结果表明,“霞石凝聚剂”——Al2(SO4)3·18H2O对去甲基金霉素发酵液中的杂质具有凝聚作用。当“霞石凝聚剂”的用量为去甲基金霉素发酵液体积的1%至3%(重量)时,可实现抗生素的乙酸丁酯萃取,且不会形成稳定的乳浊液。向发酵液中添加1%至2%(重量)的“霞石凝聚剂”,可显著提高发酵液的过滤速度。