Dal Bo L, Marcucci F, Mussini E, Perbellini D, Castellani A, Fresia P
Biopharm Drug Dispos. 1980 Jan-Mar;1(3):123-6. doi: 10.1002/bdd.2510010306.
Chlorodesmethyldiazepam (I) concentrations were followed for 72 h in the plasma of four volunteers given 2 mg of the drug orally. The drug appears to be well absorbed, reaching peak plasma levels of 20--30 ng ml-1 1--2 h after administration; 72 h after administration, plasma concentrations are still measurable (5 ng ml-1). The analytical method involved a single extraction of I from the plasma into benzene followed by centrifugation, evaporation, and gas-chromatographic analysis of the samples.
对四名口服2毫克氯去甲安定（I）的志愿者的血浆进行了72小时的跟踪监测。该药物似乎吸收良好，给药后1-2小时血浆浓度达到峰值20-30纳克/毫升；给药72小时后，血浆浓度仍可测量（5纳克/毫升）。分析方法包括将血浆中的I单次萃取到苯中，然后离心、蒸发，对样品进行气相色谱分析。
