Bareggi S R, Pirola R, Leva S, Zecca L
Eur J Drug Metab Pharmacokinet. 1986 Jul-Sep;11(3):171-4. doi: 10.1007/BF03189844.
The pharmacokinetics of chlordemethyldiazepam--a pharmacologically very active new 1,4-benzodiazepine derivative--in healthy subjects after administration of a single oral dose of 2 mg, was studied. Peak concentrations were reached in 1.2 +/- 0.2 hours. Plasma levels declined with a biphasic pattern, and the elimination phase had a half-life of 82.9 +/- 14.1 hours. The concentrations of the main metabolite of chlordemethyldiazepam, lorazepam, were about 7% of those of the parent compound. In urine only conjugated lorazepam could be found its 96 hour excretion reaching about 15% of the administered dose of parent drug.
研究了氯去甲安定（一种药理活性很强的新型1,4 -苯二氮䓬衍生物）在健康受试者单次口服2毫克后的药代动力学。1.2±0.2小时达到峰值浓度。血浆水平呈双相下降模式，消除相半衰期为82.9±14.1小时。氯去甲安定的主要代谢产物劳拉西泮的浓度约为母体化合物浓度的7%。在尿液中仅能检测到结合型劳拉西泮，其96小时排泄量约为母体药物给药剂量的15%。
