Tonoue T, Furukawa K, Nomoto T
Endocrinology. 1981 Feb;108(2):723-5. doi: 10.1210/endo-108-2-723.
A tetrodotoxin- and hexamethonium-sensitive response to thyrotropin-releasing hormone (TRH), an in vitro contraction, first appeared in the duodenum of the 3 day old rat, was increased by day 16, decreased there-after and was extinguished after weaning. A tetrodotoxin-resistant response to TRH, a relaxation, appeared at day 13 and became distinct after weaning. The development of neurogenic receptivity for TRH precedes the appearance of myogenic receptivity in the rat duodenum.
对促甲状腺激素释放激素（TRH）的河豚毒素和六甲铵敏感反应，即体外收缩反应，首次出现在3日龄大鼠的十二指肠中，在第16天时增强，之后减弱，并在断奶后消失。对TRH的河豚毒素抵抗反应，即舒张反应，出现在第13天，并在断奶后变得明显。在大鼠十二指肠中，TRH的神经源性感受性的发育先于肌源性感受性的出现。
