Furukawa K, Tonoue T, Nomoto T
Eur J Pharmacol. 1982 Aug 27;82(3-4):161-6. doi: 10.1016/0014-2999(82)90505-2.
The study concerned the postnatal ontogenesis of the response to methionine5-enkephalin (ENK) in the duodenum of developing rats. Sustained relaxation was produced by ENK in the isolated duodenum of 8 day old rats. The response was blocked by tetrodotoxin or naloxone. The response increased by day 18, decreased thereafter and was extinguished after 40 days. On the other hand, a tetrodotoxin resistant response to ENK, transient relaxation, appeared at day 20 and was augmented thereafter. The development of neurogenic receptivity for ENK preceded the appearance of myogenic receptivity in the rat duodenum.
该研究关注发育中大鼠十二指肠对甲硫氨酸脑啡肽（ENK）反应的出生后个体发生。在8日龄大鼠的离体十二指肠中，ENK可产生持续的舒张作用。该反应可被河豚毒素或纳洛酮阻断。该反应在第18天增强，此后减弱，并在40天后消失。另一方面，对ENK的河豚毒素抵抗反应，即短暂舒张，在第20天出现，并在随后增强。在大鼠十二指肠中，对ENK的神经源性感受性的发育先于肌源性感受性的出现。
