Buffoni F, Carpi C, Banchelli Soldaini G, Raimondi L
Farmaco Sci. 1980 Oct;35(10):848-55.
A series 3-hydrazinopyridazine derivatives with anti-hypertensive properties was studied as inhibitors of pyridoxal-phosphate dependent enzymes. All the compounds with a free hydrazino group were found to be strong inhibitors in vitro. In vivo inactive compounds became active at doses which exert a hypotensive action. The significance of this inhibition is discussed.
