胍那苄作为含铜胺氧化酶的抑制剂。
Guanabenz as inhibitor of copper-containing amine oxidases.
作者信息
Banchelli G, Bertocci B, Raimondi L, Soldani G, Del Tacca M, Buffoni F
出版信息
Agents Actions. 1986 Apr;18(1-2):46-8. doi: 10.1007/BF01987979.
PMID:3088929
Abstract
The effects of guanabenz on some copper containing amine oxidases are described. Guanabenz 'in vitro' inhibits pig plasma benzylamine oxidase with a IC50 M 5.1 +/- 0.8 X 10(-6) M. It also inhibits pig kidney diamine oxidase and rat liver mitochondrial monoamine oxidase at higher concentrations. The significance of this property of guanabenz is discussed.
摘要
本文描述了胍那苄对某些含铜胺氧化酶的作用。胍那苄在“体外”对猪血浆苄胺氧化酶有抑制作用，其IC50为5.1±0.8×10⁻⁶M。在较高浓度时，它还能抑制猪肾二胺氧化酶和大鼠肝线粒体单胺氧化酶。文中讨论了胍那苄这一特性的意义。
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