Franzone J S, Natale T, Cirillo R
Farmaco Sci. 1980 Jun;35(6):498-503.
The influence of oxametacine, 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-3-indoyl]acetohydroxamic acid, a new non-steroidal anti-inflammatory drug, on prostaglandin-synthetase was studied in vitro on rat spleen tissue. The drug exerts an inhibitory effect on prostaglandin biosynthesis which closely mimics that of indomethacin. On the other hand, oxametacine proves more active than other non-steroidal anti-inflammatory agents, namely ketoprofen, flufenamic acid, phenylbutazone and acetylsalicylic acid.
新型非甾体抗炎药奥沙美辛（2-[1-(4-氯苯甲酰基)-5-甲氧基-2-甲基-3-吲哚基]乙酰氧肟酸）对大鼠脾脏组织前列腺素合成酶的影响进行了体外研究。该药物对前列腺素生物合成具有抑制作用，与吲哚美辛的作用极为相似。另一方面，奥沙美辛比其他非甾体抗炎药，即酮洛芬、氟芬那酸、保泰松和乙酰水杨酸更具活性。
