Furuhashi N, Suzuki M, Fukaya T, Kono H, Tachibana Y, Shinkawa O
Gynecol Obstet Invest. 1980;11(4):231-6. doi: 10.1159/000299842.
The pituitary endocrine function in 4 anencephalic infants was studied by measuring the concentrations of growth hormone, prolactin, thyroid-stimulating hormone (TSH), follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in umbilical venous serum. There was no significant difference in hormone levels between the anencephalic and normal infants. The response of FSH and LH was negative after administration of 10 micrograms of luteinizing hormone-releasing hormone. The TSH levels after administration of 50 micrograms of TRH elevated about 4- to 6-fold over pre-administration levels. These results indicate that the hypothalamo-pituitary axis of the human fetus initiates its function from mid-pregnancy; TSH may have an autoregulating system of the pituitary itself.
通过测量脐静脉血清中生长激素、催乳素、促甲状腺激素（TSH）、促卵泡激素（FSH）和黄体生成素（LH）的浓度，对4例无脑儿婴儿的垂体内分泌功能进行了研究。无脑儿婴儿与正常婴儿的激素水平无显著差异。给予10微克黄体生成素释放激素后，FSH和LH的反应为阴性。给予50微克促甲状腺激素释放激素后，TSH水平比给药前水平升高约4至6倍。这些结果表明，人类胎儿的下丘脑 - 垂体轴在妊娠中期开始发挥功能；TSH可能具有垂体自身的自动调节系统。
