Shahmanesh M, Ali Z, Pourmand M, Nourmand I
Clin Endocrinol (Oxf). 1980 Mar;12(3):303-11. doi: 10.1111/j.1365-2265.1980.tb02714.x.
Fourteen patients with a typical history of Sheehan's syndrome underwent pituitary function tests with simultaneous injections of 100 micrograms LH-RH, 200 micrograms TRH and 0.05--0.1 units of soluble insulin per kg body weight. Serum prolactin levels remained unchanged in all of eleven subjects given TRH. GH levels did not rise after hypoglycaemia in five subjects. In contrast serum LH and FSH rose significantly in twelve out of fourteen subjects given LHRH and serum TSH rose significantly in five out of seven subjects given TRH. It is concluded that pituitary function is relatively preserved for LH and FSH but not for prolactin and GH in Sheehan's syndrome. It is further suggested that absence of a rise in prolactin following TRH stimulation may provide the most sensitive test of pituitary hypofunction in postpartum haemorrhage.
14例有典型席汉综合征病史的患者接受了垂体功能测试，同时注射每千克体重100微克促黄体生成素释放激素（LH-RH）、200微克促甲状腺激素释放激素（TRH）和0.05 - 0.1单位可溶性胰岛素。给予TRH的11名受试者中，血清催乳素水平均无变化。5名受试者低血糖后生长激素（GH）水平未升高。相比之下，给予LHRH的14名受试者中有12名血清促黄体生成素（LH）和促卵泡生成素（FSH）显著升高，给予TRH的7名受试者中有5名血清促甲状腺激素（TSH）显著升高。得出的结论是，席汉综合征患者垂体功能中LH和FSH相对保留，但催乳素和GH并非如此。进一步表明，TRH刺激后催乳素无升高可能是产后出血垂体功能减退最敏感的检测方法。
