Sheth A R, Vanage G R, Vaze A Y, Thakur A N
J Endocrinol. 1980 Dec;87(3):401-7. doi: 10.1677/joe.0.0870401.
Rabbit antiserum to human seminal plasma inhibin (hSPI) was administered subcutaneously to developing male rats of 5, 10, 14, 17 and 24 days of age and the size of the endogenous FSH rise in serum was measured. The FSH levels were threefold higher on day 9 and 1.5-fold higher on days 14 and 18 when compared with levels in control rats treated with normal rabbit serum. Furthermore, the in-vitro binding capacity of pituitary plasma membrane to 125I-labelled hSPI declined with increase in age of the rats. Thus, the results of the present study suggest that the sensitivity of the testicular inhibin-FSH feedback relationship is related to age-dependent changes in pituitary binding of inhibin.
将抗人精浆抑制素（hSPI）的兔抗血清皮下注射给5、10、14、17和24日龄的雄性幼鼠，并测量血清中内源性促卵泡激素（FSH）升高的幅度。与用正常兔血清处理的对照大鼠相比，第9天时FSH水平高出三倍，第14天和第18天时高出1.5倍。此外，垂体质膜与125I标记的hSPI的体外结合能力随大鼠年龄的增加而下降。因此，本研究结果表明，睾丸抑制素-FSH反馈关系的敏感性与抑制素垂体结合的年龄依赖性变化有关。
