Mundle S D, Sheth N A
Endocrinology Unit, Cancer Research Institute, Bombay, India.
Indian J Exp Biol. 1991 Apr;29(4):310-4.
Human seminal plasma inhibin (HSPI), of prostatic origin, has been shown to bring about a dose dependent suppression in pituitary and circulatory FSH concentrations in intact rats. No significant changes in LH levels either in pituitary or in circulation were observed at the doses used. This has further been substantiated by an immunocytochemical staining. A marked reduction in staining intensity for FSH was observed in the pituitary of inhibin treated rats as compared to the controls. None of the purified inhibin peptides from other sources have so far been reported to act on pituitary FSH in vivo. This study thus, for the first time demonstrates an in vivo effect of inhibin (HSPI) on pituitary FSH concentration and secretion.
人精浆抑制素（HSPI）起源于前列腺，已被证明能使完整大鼠的垂体和循环中促卵泡激素（FSH）浓度呈剂量依赖性降低。在所使用的剂量下，未观察到垂体或循环中促黄体生成素（LH）水平有显著变化。免疫细胞化学染色进一步证实了这一点。与对照组相比，在接受抑制素治疗的大鼠垂体中观察到FSH染色强度显著降低。迄今为止，尚未有其他来源的纯化抑制素肽在体内作用于垂体FSH的报道。因此，本研究首次证明了抑制素（HSPI）对垂体FSH浓度和分泌的体内作用。
