二氧化碳吸入对耳蜗血液循环的影响。

Effects of CO2 inhalation on cochlear blood circulation.

作者信息

Hultcrantz E, Larsen H C, Angelborg C

出版信息

ORL J Otorhinolaryngol Relat Spec. 1980;42(5):304-12. doi: 10.1159/000275512.

Abstract

The cochlear blood flow was measured with the microsphere method before, during and after CO2 inhalation in anesthetized rabbits. Different gas mixtures and exposure times were used. The greatest increase of cochlear blood flow was measured after 5 min inhalation of 7% CO2 in air (115%) and the least increase (44%) in animals breathing 7% CO2 in oxygen. The difference is explained as due to a vasoconstriction caused by a high oxygen tension counteracting the vasodilating effect of CO2. The treatment with CO2 of supposed vascular diseases in the cochlea is discussed and the negative effects due to respiratory acidosis are emphasized.

摘要

在麻醉兔身上，于吸入二氧化碳之前、期间及之后，采用微球法测量耳蜗血流量。使用了不同的气体混合物和暴露时间。在吸入7%二氧化碳与空气的混合气体5分钟后，测得耳蜗血流量增加最多（115%），而在呼吸7%二氧化碳与氧气混合气体的动物中增加最少（44%）。这种差异被解释为高氧张力引起的血管收缩抵消了二氧化碳的血管舒张作用。文中讨论了用二氧化碳治疗耳蜗假定血管疾病的方法，并强调了呼吸性酸中毒带来的负面影响。