烟酸对耳蜗血流的影响。

Effect of nicotinic acid on cochlear blood flow.

作者信息

Hultcrantz E, Hillerdal M, Angelborg C

出版信息

Arch Otorhinolaryngol. 1982;234(2):151-5. doi: 10.1007/BF00453622.

Abstract

Effects of nicotinic acid on cochlear blood flow were studied in rats by the microsphere method. One measurement was performed before drug administration and the second after i.v. injection of the nicotinic acid 25 mg/kg body weight. No measurable effect on cochlear blood flow was observed in normal animals. In one group of animals the cervical sympathetic trunks were cut and the distal part on one side was electrically stimulated during the measurements. On the unstimulated side the cochlear blood flow was significantly higher than in intact animals, but uninfluenced by nicotinic acid. On the sympathetically stimulated side a significant increase of the cochlear blood flow occurred after nicotinic acid administration.

摘要

采用微球法在大鼠中研究了烟酸对耳蜗血流的影响。在给药前进行一次测量，静脉注射25mg/kg体重的烟酸后进行第二次测量。在正常动物中未观察到对耳蜗血流有可测量的影响。在一组动物中，切断颈交感干，并在测量期间对一侧的远端进行电刺激。在未受刺激的一侧，耳蜗血流显著高于完整动物，但不受烟酸影响。在交感神经受刺激的一侧，给予烟酸后耳蜗血流显著增加。