Pankov A K, Sidorenko Iu S, Il'inskaia E G, Ogorodnikova L S, Zubkova T V
Vopr Onkol. 1981;27(1):84-8.
The results of treatment in 118 patients with ovarian cancer are presented. The sessional doses were as follows: thioTEPA--200--300 mg or cyclophosphamide--3200--4000 mg+5-fluorouracil--2000--3000 mg. Despite the fact that 116 patients had III--IV stages of the disease, the objective effect of the treatment was observed in 95 of them. Thus, the complete disappearance of tumor was gained in 3 cases, reduction of the tumor size more than by 50%--in 68 patients, more than by 25%--in 18, an insignificant diminishing of tumor, the appearance of its mobility--in 13. Surgical intervention has been performed in 96 patients, that makes 82% of the operability. Supravaginal amputation of the uterus with adnexa and extirpation of the greater omentum have been performed in 76 cases, that yields 67% of resectability. Sole tumors have been removed in 11 patients, the intervention being confined to laparotomy in 6 (5.1%). Pronounced degenerative and necrobiotic alterations in the tumor were revealed by its histochemical assay in 22 patients 40, 50 and 60 days after endolymphatic infusion of chemotherapeutic drugs.
本文介绍了118例卵巢癌患者的治疗结果。疗程剂量如下：噻替派——200——300毫克，或环磷酰胺——3200——4000毫克+5-氟尿嘧啶——2000——3000毫克。尽管116例患者处于疾病的III——IV期，但其中95例观察到了治疗的客观效果。因此，3例患者肿瘤完全消失，68例患者肿瘤大小缩小超过50%，18例患者肿瘤大小缩小超过25%，13例患者肿瘤略有缩小且出现活动度。96例患者接受了手术干预，手术成功率为82%。76例患者进行了子宫及附件的阴道上截肢术和大网膜切除术，切除率为67%。11例患者切除了单个肿瘤，6例（5.1%）仅进行了剖腹手术。在淋巴内注入化疗药物后40、50和60天，对22例患者的肿瘤进行组织化学分析，发现肿瘤有明显的变性和坏死改变。
