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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Pipy B, Gaillard D, Beraud M, Derache R

Xenobiotica. 1980 Oct;10(10):785-93. doi: 10.3109/00498258009033807.

The pharmacokinetics of [14C]carbaryl administered intravenously and orally were studied in male rats whose reticuloendothelial system (RES) was inhibited by colloidal carbon or activated by glyceryl trioleate. 2. A time course for [14C]carbaryl blood concn. was fitted to a two-compartment open model following single intravenous administration. A single exponential decay was noted following intragastric administration. 3. The constant blood elimination of [14C]carbaryl decreased significantly in animals with the RES inhibited and increased in those whose RES was activated compared to control animals. 4. There was an increase in carbaryl concn. in the tissue compartment in animals with the RES activated, but no change in animals with the RES inhibited. 5. The equivalent [14C]carbaryl concn. of liver and lungs were decreased or increased in animals with the RES inhibited or activated respectively.

在雄性大鼠中研究了静脉内和口服给予[14C]西维因的药代动力学，这些大鼠的网状内皮系统（RES）被胶体碳抑制或被三油酸甘油酯激活。2. 单次静脉给药后，[14C]西维因血药浓度的时间进程符合二室开放模型。胃内给药后呈现单指数衰减。3. 与对照动物相比，RES被抑制的动物中[14C]西维因的持续血液消除显著降低，而RES被激活的动物中则增加。4. RES被激活的动物组织隔室中西维因浓度增加，但RES被抑制的动物中无变化。5. RES被抑制或激活的动物中，肝脏和肺的等效[14C]西维因浓度分别降低或增加。

Pipy B, Gaillard D, Beraud M, Derache R

Xenobiotica. 1980 Oct;10(10):785-93. doi: 10.3109/00498258009033807.

The pharmacokinetics of [14C]carbaryl administered intravenously and orally were studied in male rats whose reticuloendothelial system (RES) was inhibited by colloidal carbon or activated by glyceryl trioleate. 2. A time course for [14C]carbaryl blood concn. was fitted to a two-compartment open model following single intravenous administration. A single exponential decay was noted following intragastric administration. 3. The constant blood elimination of [14C]carbaryl decreased significantly in animals with the RES inhibited and increased in those whose RES was activated compared to control animals. 4. There was an increase in carbaryl concn. in the tissue compartment in animals with the RES activated, but no change in animals with the RES inhibited. 5. The equivalent [14C]carbaryl concn. of liver and lungs were decreased or increased in animals with the RES inhibited or activated respectively.

在雄性大鼠中研究了静脉内和口服给予[14C]西维因的药代动力学，这些大鼠的网状内皮系统（RES）被胶体碳抑制或被三油酸甘油酯激活。2. 单次静脉给药后，[14C]西维因血药浓度的时间进程符合二室开放模型。胃内给药后呈现单指数衰减。3. 与对照动物相比，RES被抑制的动物中[14C]西维因的持续血液消除显著降低，而RES被激活的动物中则增加。4. RES被激活的动物组织隔室中西维因浓度增加，但RES被抑制的动物中无变化。5. RES被抑制或激活的动物中，肝脏和肺的等效[14C]西维因浓度分别降低或增加。