Schopp R T
Arch Int Pharmacodyn Ther. 1978 Apr;232(2):235-45.
Manganese is reported to interfere with transmitter release at a number of neuroeffector junctions. This effect is apparently related to competition between manganese and calcium for sites on the prejunctional terminals. Thus manganese can block the entry of calcium into the prejunctional terminals, an essential step in the excitation-secretion process. 5-Hydroxytryptamine, epinephrine, neostigmine, potassium chloride and calcium chloride have been investigated with respect to antagonism to partial paralysis induced with manganese chloride in canine peronealtibialis anterior, nerve-muscle preparations. Close intra-arterial injection of any of these substances manifested some degree of antagonism to manganese partial paralysis. Calcium was found to be the most effective antagonist. Post-tetanic facilitation was demonstrated during partial manganese block. Manganese was found to be seven times more effective than magnesium in producing paralysis.
据报道，锰会干扰多个神经效应器接头处的递质释放。这种效应显然与锰和钙在神经节前终末位点上的竞争有关。因此，锰可阻断钙进入神经节前终末，而这是兴奋 - 分泌过程中的一个关键步骤。就对犬腓骨长肌 - 胫前肌神经 - 肌肉制备物中由氯化锰诱导的部分麻痹的拮抗作用而言，已对5 - 羟色胺、肾上腺素、新斯的明、氯化钾和氯化钙进行了研究。经动脉内近距离注射这些物质中的任何一种，均表现出对锰所致部分麻痹的一定程度的拮抗作用。发现钙是最有效的拮抗剂。在部分锰阻滞期间证实存在强直后易化现象。发现锰在产生麻痹方面的效力比镁高7倍。
