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解磷定二氢衍生物（pro-2-PAM）在有机磷中毒中的中枢治疗作用。

Central therapeutic effects of dihydroderivative of pralidoxime (pro-2-PAM) in organophosphate intoxication.

作者信息

Rump S, Faff J, Borkowska G, Ilczuk I, Rabsztyn T

出版信息

Arch Int Pharmacodyn Ther. 1978 Apr;232(2):321-32.

PMID:677965
Abstract

Central actions of pro-2-PAM (dihydroderivative of 2-PAM) and 2-PAM in poisonings with DFP have been studied. It was shown that pro-2-PAM significantly increased activity of DFP inhibited acetylcholinesterase in the brain, quickly ceased the DFP-induced paralysis of respiration, partially normalized the DFP-induced abnormalities in electrocorticogram and increased the convulsive dosis of DFP. Effects of 2-PAM in these experiments were negligible.

摘要

已对解磷定（2 - 吡啶甲醛肟的二氢衍生物）和2 - 吡啶甲醛肟（2 - PAM）在二异丙基氟磷酸酯（DFP）中毒中的中枢作用进行了研究。结果表明，解磷定显著提高了DFP抑制的脑内乙酰胆碱酯酶的活性，迅速终止了DFP诱导的呼吸麻痹，部分使DFP诱导的脑电图异常恢复正常，并提高了DFP的惊厥剂量。在这些实验中，2 - 吡啶甲醛肟的作用可忽略不计。

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