Périer P, Fabiani J N, Bocher M, Massoud H, Carpentier A, Dubost C
Arch Mal Coeur Vaiss. 1980 Jun;73(6):713-8.
The effects of the addition of 20 mg sodium allopurinate to a litre of ionic cardioplegic solution were studied. The experimental model was the working isolated perfused rat heart in oxygenated Krebs-Henseleit solution. The cardiac outputs were compared after 1 hour of ischaemia with three different methods of myocardial protection; group I: protection by hypothermia at 4 degrees C, group II: protection by ionic cardioplegic solution A, group III: by ionic cardioplegic solution B (with 20 mg Allopurinol). The results were expressed in percentage of the preischemic cardiac output. The best results were obtained in group III, especially after 15 minutes recovery (80.7 +/- 4.5 p. 100 at 15 minutes, 90.6 +/- 3.1 p. 100 at 30 minutes., 88.3 +/- 4.6 p. 100 at 1 hour). The results in group II were significantly better than in group I after 10 minutes recovery. Myocardial protection bu ionic cardioplegia associated with hypothermia at 4 degrees C gives a better post ischaemic recovery than hypothermia alone. When allopurinol is added to the cardioplegic solution, the protection is increased. These effects are similar to the haemodynamic effects of allopurinol on ischaemic myocardium together with the possible limitation of experimental myocardial infarction with regression of the oedema that has been observed with this drug.
研究了在一升离子心脏停搏液中添加20毫克别嘌呤醇钠的效果。实验模型是在含氧的克雷布斯-亨泽莱特溶液中工作的离体灌注大鼠心脏。采用三种不同的心肌保护方法，比较缺血1小时后的心脏输出量；第一组：4℃低温保护，第二组：离子心脏停搏液A保护，第三组：离子心脏停搏液B（含20毫克别嘌呤醇）保护。结果以缺血前心脏输出量的百分比表示。第三组取得了最佳结果，尤其是在恢复15分钟后（15分钟时为80.7±4.5%，30分钟时为90.6±3.1%，1小时时为88.3±4.6%）。恢复10分钟后，第二组的结果明显优于第一组。4℃低温联合离子心脏停搏液的心肌保护比单纯低温能带来更好的缺血后恢复。当别嘌呤醇添加到心脏停搏液中时，保护作用增强。这些作用类似于别嘌呤醇对缺血心肌的血流动力学作用，以及可能限制实验性心肌梗死，并使已观察到的该药物引起的水肿消退。
