Schlippert W
Arch Intern Med. 1978 Aug;138(8):1257-60. doi: 10.1001/archinte.138.8.1257.
Cimetidine is an H2-receptor antagonist that is capable of marked suppression of gastric acid and pepsin secretion. Patients with active duodenal ulcer disease treated with cimetidine show improved rates of healing and symptom relief compared with placebo-treated controls. Peptic ulcer and diarrhea of Zollinger-Ellison syndrome and other acid hypersecretory states respond to cimetidine treatment, as may stress ulcers and steatorrhea of patients with pancreatic insuffficiency who have a suboptimol response to oral pancreatin. Effectiveness with gastric ulcer has been less convincing than with duodenal ulcer. In duodenal ulcer disease, cimetidine need not replace less expensive antacid therapy in most cases and is unlikely to replace definitive surgery for suitable candidates.
西咪替丁是一种H2受体拮抗剂，能够显著抑制胃酸和胃蛋白酶分泌。与接受安慰剂治疗的对照组相比，接受西咪替丁治疗的活动性十二指肠溃疡病患者愈合率提高，症状缓解。卓艾综合征和其他胃酸分泌过多状态的消化性溃疡和腹泻对西咪替丁治疗有反应，胰腺功能不全患者对应口服胰酶反应欠佳时出现的应激性溃疡和脂肪泻也可能对西咪替丁有反应。胃溃疡的治疗效果不如十二指肠溃疡那样令人信服。在十二指肠溃疡病中，在大多数情况下西咪替丁无需取代成本较低的抗酸治疗，对于合适的患者也不太可能取代确定性手术。
