Brunner H
Acta Med Austriaca. 1978;5(2):36-40.
The treatment of gastric ulcer by the H2-receptor-antagonist Cimetidine results in an ulcer healing rate of 60 to 80% during a 4 to 6 weeks therapy cure. In most studies Cimetidine is superior to placebo or equipotent to a high dose antacid regimen, the latter being accepted to be of beneficial effect on ulcer healing. In the Zollinger-Ellison-syndrome Cimetidine inhibits largely gastric acid hypersecretion and represents for the first time a true alternative to total gastrectomy.
使用H2受体拮抗剂西咪替丁治疗胃溃疡，在4至6周的治疗疗程中，溃疡愈合率为60%至80%。在大多数研究中，西咪替丁优于安慰剂，或与高剂量抗酸剂疗法等效，后者被认为对溃疡愈合有有益作用。在卓-艾综合征中，西咪替丁在很大程度上抑制胃酸分泌过多，首次成为全胃切除术的真正替代方法。
