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分离出的脑微血管中去甲肾上腺素及相关酶的存在情况。

Presence of norepinephrine and related enzymes in isolated brain microvessels.

作者信息

Lai F M, Udenfriend S, Spector S

出版信息

Proc Natl Acad Sci U S A. 1975 Nov;72(11):4622-5. doi: 10.1073/pnas.72.11.4622.

DOI:10.1073/pnas.72.11.4622
PMID:678
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC388775/
Abstract

Norepinephrine and the enzymes involved in its synthesis and degradation were found to be associated with isolated brain microvessels. The significance of these results are discussed with respect to adrenergic innervation of the cerebral microvessels and thereby neural regulation of the cerebral microcirculation.

摘要

去甲肾上腺素及其合成与降解过程中涉及的酶被发现与分离出的脑微血管相关。就脑微血管的肾上腺素能神经支配以及由此产生的脑微循环的神经调节而言，对这些结果的意义进行了讨论。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3790/388775/701014a32eeb/pnas00062-0438-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3790/388775/03bc3ef0a4cf/pnas00062-0437-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3790/388775/edbfcc082e7d/pnas00062-0437-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3790/388775/701014a32eeb/pnas00062-0438-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3790/388775/03bc3ef0a4cf/pnas00062-0437-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3790/388775/edbfcc082e7d/pnas00062-0437-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3790/388775/701014a32eeb/pnas00062-0438-a.jpg

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引用本文的文献

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本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
A RAPID AND SIMPLE RADIOASSAY FOR TYROSINE HYDROXYLASE ACTIVITY.一种快速简便的酪氨酸羟化酶活性放射测定法。
Anal Biochem. 1964 Sep;9:122-6. doi: 10.1016/0003-2697(64)90092-2.
3
Dopamine formation in brain capillaries--an enzymic blood-brain barrier mechanism.脑毛细血管中的多巴胺生成——一种酶促血脑屏障机制。
从牛海绵体中高产率分离代谢活跃的内皮细胞。一种用于对新鲜分离的微血管内皮细胞进行功能研究的模型。
Cell Tissue Res. 1983;232(3):579-91. doi: 10.1007/BF00216430.
4
Copper in brain.大脑中的铜
Neurochem Res. 1983 Oct;8(10):1211-32. doi: 10.1007/BF00963993.
5
Correlation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity with blood-brain barrier monoamine oxidase activity.1-甲基-4-苯基-1,2,3,6-四氢吡啶神经毒性与血脑屏障单胺氧化酶活性的相关性。
Proc Natl Acad Sci U S A. 1987 May;84(10):3521-5. doi: 10.1073/pnas.84.10.3521.
6
Metabolism and nervous system disease: a challenge for our times. Part II.代谢与神经系统疾病：当代面临的一项挑战。第二部分。
Metab Brain Dis. 1986 Jun;1(2):91-117. doi: 10.1007/BF00999381.
7
Neuronal control of brain microvessel function.脑微血管功能的神经元控制
Experientia. 1985 Apr 15;41(4):427-34. doi: 10.1007/BF01966140.
8
Brain and vascular monoamine oxidase activity in the deoxycorticosterone-salt hypertensive rat.脱氧皮质酮-盐性高血压大鼠的脑和血管单胺氧化酶活性
Br J Pharmacol. 1977 Mar;59(3):393-5. doi: 10.1111/j.1476-5381.1977.tb08391.x.
9
Isolated microvessels: the blood-brain barrier in vitro.分离的微血管：体外血脑屏障
Proc Natl Acad Sci U S A. 1978 Sep;75(9):4544-8. doi: 10.1073/pnas.75.9.4544.
J Neurochem. 1967 May;14(5):547-50. doi: 10.1111/j.1471-4159.1967.tb09553.x.
4
The localization of monoaminergic blood-brain barrier mechanisms.单胺能血脑屏障机制的定位
Pharmacol Rev. 1966 Mar;18(1):369-85.
5
The innervation of the cerebral arteries in the rat: an electron microscope study.大鼠脑动脉的神经支配：一项电子显微镜研究。
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6
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7
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8
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9
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Arch Biochem Biophys. 1970 Nov;141(1):356-67. doi: 10.1016/0003-9861(70)90144-x.
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