Shu C D, Chang T M
Int J Artif Organs. 1980 Sep;3(5):287-91.
The in vitro removal of tyrosine by means of perfusion over immobilized tyrosinase within artificial cells was studied. The assayed activity of the microencapsulated tyrosinase was about half the value of the same amount of enzyme in free solution. Further studies were conducted to determine the stability, kinetics, and clearance of this system. The results obtained suggest that immobilized tyrosinase within artificial cells is efficient in removing tyrosine in vitro and further study in an animal model is feasible.
研究了通过在人工细胞内固定化酪氨酸酶上进行灌注来体外去除酪氨酸的方法。微囊化酪氨酸酶的测定活性约为相同量游离溶液中酶活性的一半。进行了进一步的研究以确定该系统的稳定性、动力学和清除率。所得结果表明，人工细胞内固定化酪氨酸酶在体外去除酪氨酸方面是有效的，并且在动物模型中进行进一步研究是可行的。
