Shu C D, Chang T M
Int J Artif Organs. 1981 Mar;4(2):82-5.
Galactosamine-induced fulminant hepatic failure rats were used for in vivo studies of the removal of tyrosine and total free phenol by means of hemoperfusion over immobilized tyrosinase within artificial cells. The elevated plasma tyrosine level was decreased to about half the value after one hour of hemoperfusion. The studies of tyrosine clearance suggest that it is efficient and remains constant throughout the one-hour hemoperfusion. In those galactosamine-induced fulminant hepatic failure rats with increased total free phenol levels hemoperfusion over tyrosinase artificial cells significantly lowered the level.
将半乳糖胺诱导的暴发性肝衰竭大鼠用于体内研究，通过在人工细胞内固定化酪氨酸酶进行血液灌流来去除酪氨酸和总游离酚。血液灌流1小时后，升高的血浆酪氨酸水平降至约一半。酪氨酸清除率的研究表明，在整个1小时的血液灌流过程中，其清除效率高且保持恒定。在那些总游离酚水平升高的半乳糖胺诱导的暴发性肝衰竭大鼠中，通过酪氨酸酶人工细胞进行血液灌流可显著降低该水平。
