Linkowski P, Brauman H, Mendlewicz J
Br J Psychiatry. 1980 Sep;137:229-32. doi: 10.1192/bjp.137.3.229.
Plasma growth hormone (GH) release after TRH injection was investigated in 27 unipolar and 23 bipolar depressive women, and in 39 normal female controls matched for age, sex and menopausal status. Peaks of GH secretion after TRH were observed in some depressive patients as well as in some normal controls, but there were no significant differences in GH response after TRH administration between patients and controls. The implications of these findings are discussed in reference to such factors as non-specific stress responses and abnormal neuroendocrine circadian rhythms in affectively ill patients.
对27名单相抑郁女性、23名双相抑郁女性以及39名年龄、性别和绝经状态相匹配的正常女性对照者，研究了注射促甲状腺激素释放激素（TRH）后血浆生长激素（GH）的释放情况。在一些抑郁患者以及一些正常对照者中观察到了TRH注射后的GH分泌峰值，但患者和对照者在给予TRH后的GH反应方面没有显著差异。结合诸如情感性疾病患者的非特异性应激反应和异常神经内分泌昼夜节律等因素，对这些发现的意义进行了讨论。
