Ivasenko I N
Arkh Anat Gistol Embriol. 1978 Apr;74(4):79-84.
By the method of autoradiography, the proliferative pool in the epithelia covering the vagina, uterine body and its glands was investigated in ovariectomized rats treated with oestradiol alone and in combination with progesterone, under repeated injections of 3H-thymedine for 24 h. None of the epithelia studied demonstrated the proliferative pool more than 80%. Oestradiol and oestradiol in combination with progesterone produced a considerable increase in the size of proliferating cell population in the vaginal and uterine epithlia in comparison with the control animals. In the vaginal epithelium, progesterone decreased the proliferative pool and inhibited migration of the labeled cells towards the superficial epithelial layer comparing with the injection of oestradiol alone. In the epithelium covering the uterus body, progesterone increased the size of proliferative cell population and delayed their rejection into the uterus cavity. In the epithelium of the uterus glands, there was no statistically significant differences in the amount of labeled cells by the end of the experiment both after oestradiol injection and after simultaneous injection of oestradiol and progesterone.
采用放射自显影法，对单独注射雌二醇以及同时注射雌二醇和孕酮的去卵巢大鼠，在连续24小时注射³H-胸腺嘧啶核苷的情况下，研究了覆盖阴道、子宫体及其腺体的上皮组织中的增殖池。所研究的上皮组织均未显示增殖池超过80%。与对照动物相比，雌二醇以及雌二醇与孕酮联合使用，使阴道和子宫上皮组织中增殖细胞群的大小显著增加。在阴道上皮中，与单独注射雌二醇相比，孕酮减少了增殖池，并抑制标记细胞向表层上皮层的迁移。在覆盖子宫体的上皮组织中，孕酮增加了增殖细胞群的大小，并延迟其向子宫腔的排出。在子宫腺体的上皮组织中，在实验结束时，注射雌二醇后以及同时注射雌二醇和孕酮后，标记细胞数量没有统计学上的显著差异。
