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[雌二醇与孕酮联合给药对去卵巢白色大鼠生殖道上皮组织有丝分裂周期的影响]

[Effect of combined administration of estradiol and progesterone on the mitotic cycle of the epithelial tissues of the reproductive tract of ovariectomized white rats].

作者信息

Ivasenko I N, Prianishnikov V A

出版信息

Tsitologiia. 1978 Mar;20(3):307-14.

PMID:684840
Abstract

The duration of stages of the cell cycle in the uterine and vaginal tissues of ovariectomized rats, treated with estradiol and estradiol-progesterone, was estimated using the labeled mitosis method. The joint treatment shortened G2 period in epithelial tissues. In the uterine epithelial tissues of estradiol-progesterone treated rats, the duration of S period was prolonged. In all tissues, progesterone stimulated the entry of cells into a second round of DNA synthesis. The estrogen-gestagen treatment inhibited the movement of vaginal epithelial cells from basal to superficial layers.

摘要

采用标记有丝分裂法估算了用雌二醇和雌二醇 - 孕酮处理的去卵巢大鼠子宫和阴道组织中细胞周期各阶段的持续时间。联合处理缩短了上皮组织中的G2期。在经雌二醇 - 孕酮处理的大鼠子宫上皮组织中,S期持续时间延长。在所有组织中,孕酮刺激细胞进入第二轮DNA合成。雌激素 - 孕激素处理抑制了阴道上皮细胞从基底层向表层的移动。

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