Robert F, Durant J R, Gams R A
Arch Intern Med. 1977 May;137(5):688-90.
Disseminated cryptococcosis is seen with increased frequency in patients with malignant hematologic disease. Usually the diagnosis rests on spinal fluid studies, and little attention has been paid to the direct examination of a bone marrow specimen. A febrile woman with an advanced histiocytic lymphoma was intensively treated with antineoplastic agents; the antemortem diagnosis of cryptococcosis was suspected from direct examination of the bone marrow and was subsequently confirmed by culture. Visualization of fungi in special stained bone marrow specimens could be useful in the initial examination of febrile patients with neoplastic diseases and/or compromised host defenses, and would permit early institution of specific therapy.
播散性隐球菌病在恶性血液病患者中的发病率日益增高。通常情况下，诊断依赖于脑脊液检查，而骨髓标本的直接检查很少受到关注。一名患有晚期组织细胞淋巴瘤的发热女性接受了强化抗肿瘤药物治疗；通过骨髓直接检查怀疑生前患有隐球菌病，随后经培养得以证实。在特殊染色的骨髓标本中观察到真菌，这对于发热的肿瘤疾病患者和/或宿主防御功能受损患者的初步检查可能有用，并且能够允许早期进行特异性治疗。
