内源性过氧化物酶活性的批判性研究：其在大鼠胎儿甲状腺滤泡形态功能环境中的作用。

Critical study of endogenous peroxidase activity: its role in the morphofunctional setting of the thyroid follicle in the rat fetus.

作者信息

Remy L, Michel-Bechet M, Athouel-Haon A M, Magre S

出版信息

Acta Histochem. 1980;67(2):159-72. doi: 10.1016/S0065-1281(80)80020-1.

Abstract

Endogenous peroxidase is associated with thyroglobulin iodination. It first appears at 17 day of pregnancy in rat fetal thyroid and seems to be synthesized within the perinuclear cistern and the rough endoplasmic reticulum. Then, the enzyme is transferred by vesicles up to the follicular lumen where thyroglobulin iodination takes place. The different steps of this process can occur within a very short time, since peroxidase activity is already located in the apical plasma membrane of follicles formed as early as 17 days of pregnancy, which is consistent with autoradiographic data showing iodinated thyroglobulin at 17 days. It can be concluded that the follicle is functional as soon as it is formed.

摘要

内源性过氧化物酶与甲状腺球蛋白碘化作用相关。它最早出现在大鼠胎儿甲状腺妊娠第17天时，似乎是在核周池和粗面内质网内合成的。然后，该酶通过囊泡转运至发生甲状腺球蛋白碘化作用的滤泡腔。这一过程的不同步骤可在极短时间内发生，因为早在妊娠第17天时形成的滤泡顶端质膜中就已存在过氧化物酶活性，这与放射自显影数据显示在第17天时甲状腺球蛋白碘化的结果一致。可以得出结论，滤泡一旦形成即具备功能。