Young G A, Hill G L
Am J Clin Nutr. 1981 Feb;34(2):166-72. doi: 10.1093/ajcn/34.2.166.
Eight plasma proteins, four anthropometric measurements, and 21 amino acids were measured in 24 fasting patients before surgery. A matrix of partial correlation coefficients, correcting for age and height, showed many correlations including several between biochemical and anthropometric data such as between valine or prealbumin and arm muscle circumference. Valine was the most highly correlated variable and was used to rank and group the patients. Ten patients with low valine had the greatest weight loss and also had low values for 18 variables which could be subdivided. 1) Thirteen of the low variables were interrelated and correlated with valine, i.e., arm muscle circumference, prealbumin, retinol-binding protein, transferrin, haemoglobin, isoleucine, leucine, methionine, phenylalanine, tyrosine, serine, alanine, and proline. 2) Fat, threonine, glycine, and beta-lipoprotein were interrelated with one another but not with the larger group. Only beta-lipoprotein were interrelated with one another but not with the larger group. Only beta-lipoprotein correlated with valine. It is suggested that variables in both groups reflect protein-energy malnutrition but that those in the second group are affected predominantly by energy intake.
在24名手术前禁食的患者中测量了8种血浆蛋白、4种人体测量指标和21种氨基酸。校正年龄和身高后的偏相关系数矩阵显示出许多相关性，包括生化数据与人体测量数据之间的若干相关性，如缬氨酸或前白蛋白与上臂肌肉周长之间的相关性。缬氨酸是相关性最高的变量，被用于对患者进行排名和分组。10名缬氨酸水平低的患者体重减轻最多，并且在18个可细分的变量上也有低值。1）13个低值变量相互关联且与缬氨酸相关，即上臂肌肉周长、前白蛋白、视黄醇结合蛋白、转铁蛋白、血红蛋白、异亮氨酸、亮氨酸、蛋氨酸、苯丙氨酸、酪氨酸、丝氨酸、丙氨酸和脯氨酸。2）脂肪、苏氨酸、甘氨酸和β-脂蛋白相互关联，但与较大的一组不相关。只有β-脂蛋白相互关联，但与较大的一组不相关。只有β-脂蛋白与缬氨酸相关。提示两组变量均反映蛋白质-能量营养不良，但第二组变量主要受能量摄入影响。
