Metzger J P, Loisance D, Bor J, Dumas P, Pelat P, Rojano-Gusman A, Heulin A
Arch Mal Coeur Vaiss. 1981 Feb;74(2):231-6.
The cause of recurrent resting angina one year after aorto-coronary bypass is presented. A 65 year old female with effort and resting angina with syncope had an isolated narrowing of the proximal portion of the left anterior descending artery on coronary angiography. Saphenous vein aorto-coronary bypass and cardiac plexectomy were performed on the 18 . 12 . 78, and an excellent result was obtained in the first postoperative year. Nocturnal angina with syncope recurred on the 31 . 12 . 79 and anterior subendo-cardial ischaemic changes were noted on the post critical electrocardiogramme. On control angiography 10 days later, the bypass graft was shown to be patent. A provocative test with methylergometrine showed spasm of the whole of the revascularised artery without any changes in the other vessels. Attacks of spontaneous angina with ST depression on Holter monitoring continued despite treatment with Nifedipine (6 capsules/day). The substitution of Diltiazem (3 capsules/day) prevented further recurrence with a follow-up of three months. The authors conclude that spontaneous angina after aorto-coronary bypass is not synonymous with graft dysfunction, and suggest that the effects of cardiac denervation in vasospastic angina, where Nifedipine and Diltiazem seem to have different modes of action, need further confirmation.
本文介绍了主动脉冠状动脉搭桥术后一年复发性静息性心绞痛的病因。一名65岁女性,有劳力性和静息性心绞痛伴晕厥,冠状动脉造影显示左前降支近端孤立性狭窄。1978年12月18日进行了大隐静脉主动脉冠状动脉搭桥术和心脏神经丛切除术,术后第一年效果良好。1979年12月31日夜间心绞痛伴晕厥复发,心电图显示临界状态后有前壁心内膜下缺血性改变。10天后的对照血管造影显示搭桥血管通畅。用甲基麦角新碱进行激发试验显示,整个血管重建的动脉发生痉挛,其他血管无任何变化。尽管使用硝苯地平(6粒/天)治疗,但动态心电图监测仍显示有自发性心绞痛伴ST段压低发作。改用地尔硫䓬(3粒/天)后,随访三个月未再复发。作者得出结论,主动脉冠状动脉搭桥术后的自发性心绞痛并非移植血管功能障碍的同义词,并指出在血管痉挛性心绞痛中,心脏去神经支配的作用,硝苯地平和地尔硫䓬似乎有不同的作用方式,需要进一步证实。