Bertrand M E, Lablanche J M, Tilmant P Y, Thieuleux F A, Hethuin J M, Warembourg H, Stankowiak C, Soots G
Arch Mal Coeur Vaiss. 1982 May;75(5):575-82.
The results of coronary bypass surgery are generally not as good in Prinzmetal angina as in classical angina pectoris. The percentage of myocardial infarction, recurrent angina and death is much higher. One reason for these failures could be the persistence of coronary spasm. In order to prevent this, denervation of the pre-supra and retro aortic nerve plexuses was carried out in 56 patients (54 male, 2 female) with Prinzmetal angina and operable coronary arterial lesions. Forty patients had documented coronary spasm mainly of the left anterior descending (20 cases) or the right coronary artery (13 cases). Surgery consisted of cardiac denervation associated with direct myocardial revascularisation by implantation of I (37 cases), 2 (13 cases) or 3 (6 cases) aorto coronary bypass grafts. Two deaths were observed in the perioperative period (one low output syndrome and one severe arrhythmia) and one myocardial infarction in the postoperative period. Of the 54 survivors, 49 are asymptomatic and 2 have recurrent spontaneous angina. Exercise electrocardiography in 44 patients was negative in 40 cases. Continuous electrocardiographic recordings (Holter method) in 33 patients was negative for ischemia and of 25 bypass grafts controlled, 24 were patent. Seventy five methylergometrine provocation tests were performed: only 2 were positive, both in patients with recurrent attacks. Therefore, with respect to the total numbers of recurrent angina (2), post operative infarction (I), peri and post operative deaths (3), the percentage of poor results was only 10,7 p. 100, almost three times lower than in previously reported series. In conclusion, we can say that the association of cardiac denervation with coronary bypass surgery significantly improves the percentage of good results (89,3 p. 100 of patients presenting with Prinzmetal angina).
冠状动脉搭桥手术治疗变异型心绞痛的效果通常不如典型心绞痛。心肌梗死、复发性心绞痛和死亡的发生率要高得多。这些手术失败的一个原因可能是冠状动脉痉挛持续存在。为了预防这种情况,对56例(54例男性,2例女性)患有变异型心绞痛且有可手术治疗的冠状动脉病变的患者进行了主动脉上和主动脉后神经丛去神经支配。40例患者记录有冠状动脉痉挛,主要累及左前降支(20例)或右冠状动脉(13例)。手术包括心脏去神经支配并通过植入1条(37例)、2条(13例)或3条(6例)主动脉冠状动脉搭桥进行直接心肌血运重建。围手术期观察到2例死亡(1例低心排综合征和1例严重心律失常),术后观察到1例心肌梗死。在54名幸存者中,49例无症状,2例有复发性自发性心绞痛。44例患者的运动心电图检查中,40例结果为阴性。33例患者的连续心电图记录(动态心电图法)未发现缺血,在25条接受检查的搭桥血管中,24条通畅。进行了75次甲基麦角新碱激发试验:仅2例阳性,均为复发性发作的患者。因此,就复发性心绞痛(2例)、术后梗死(1例)、围手术期和术后死亡(3例)的总数而言,不良结果的百分比仅为10.7%,几乎比先前报道的系列低三倍。总之,我们可以说心脏去神经支配与冠状动脉搭桥手术相结合显著提高了良好结果的百分比(变异型心绞痛患者中89.3%)。