Enomoto H, Yoshikuni Y, Saito K, Ozaki T, Ohata K, Zschocke R
Atherosclerosis. 1978 Jun;30(2):109-21. doi: 10.1016/0021-9150(78)90054-0.
The influence of THD-341, N-(2,6-dimethylphenyl)-delta8-dihydroabietamide, upon the formation and regression of atherosclerosis and on serum and liver lipid levels has been studied. When rabbits were fed a 1% cholesterol diet for 7 weeks, THD-341 added at a dietary level of 0.01% during the last 4 weeks almost completely prevented the formation of atherosclerotic lesions and the elevation of serum and liver cholesterol levels. When the drug was fed for 10 weeks, either in the normal or cholesterol diet, to rabbits with pre-established atherosclerosis induced by cholesterol feeding for 11 weeks, it did not affect the extent or severity of the lesions but inhibited the progression of lipid deposition in the aorta in a group fed the cholesterol diet during the final 10-weeks period. The reduction of serum and liver cholesterol levels was greater in the drug-treated groups than in the normal rabbit chow-fed group.
研究了THD - 341，即N - (2,6 - 二甲基苯基)-δ8 - 二氢枞酰胺，对动脉粥样硬化的形成与消退以及血清和肝脏脂质水平的影响。给兔子喂食1%胆固醇饮食7周，在最后4周添加0.01%饮食水平的THD - 341，几乎完全阻止了动脉粥样硬化病变的形成以及血清和肝脏胆固醇水平的升高。当给通过喂食11周胆固醇诱导出动脉粥样硬化的兔子喂食该药物10周时，无论是在正常饮食还是胆固醇饮食情况下，它都不影响病变的范围或严重程度，但在最后10周喂食胆固醇饮食的一组兔子中，它抑制了主动脉中脂质沉积的进展。药物治疗组血清和肝脏胆固醇水平的降低幅度大于正常兔粮喂养组。
