Petit J C, Sicard D, Bayo S, Daguet G L
Can J Microbiol. 1981 Jan;27(1):93-7. doi: 10.1139/m81-015.
Experimental pyelonephritis was produced in mice by the intravenous injection of Pseudomonas aeruginosa. Immune response to infection was studied by passive hemagglutination antibody titers. Vaccination of mice with live P. aeruginosa or culture filtrates (Pseudomonas antigen) induced antibodies and resulted in a high degree of protection against death and pyelonephritis following subsequent hematogenous challenge with the homologous strain. Transfer of immune serum protected mice against death following infection with the homologous strain and with a heterologous strain. However, immune serum failed to protect mice from kidney infection by the heterologous strain. These data indicate that immune serum seemed to protect against early, overwhelming bacteremia but did not prevent a chronic course of kidney infection by a heterologous strain.
通过静脉注射铜绿假单胞菌在小鼠中诱发实验性肾盂肾炎。通过被动血凝抗体滴度研究对感染的免疫反应。用活的铜绿假单胞菌或培养滤液（铜绿假单胞菌抗原）对小鼠进行疫苗接种可诱导产生抗体，并在随后用同源菌株进行血源性攻击后，对死亡和肾盂肾炎产生高度保护作用。免疫血清的转移可保护小鼠免受同源菌株和异源菌株感染后的死亡。然而，免疫血清未能保护小鼠免受异源菌株引起的肾脏感染。这些数据表明，免疫血清似乎可预防早期的、压倒性的菌血症，但不能预防异源菌株引起的肾脏感染的慢性病程。
