B淋巴细胞和T淋巴细胞对脱氧鸟苷的磷酸化作用：嘌呤核苷磷酸化酶缺乏时T淋巴细胞选择性捕获脱氧鸟苷的反证。
Phosphorylation of deoxyguanosine by B and T lymphocytes: evidence against selective trapping of deoxyguanosine by T lymphocytes in purine nucleoside phosphorylase deficiency.
作者信息
North M E, Newton C A, Webster A D
出版信息
Clin Exp Immunol. 1980 Dec;42(3):523-9.
Abstract
T and B lymphocytes from blood and tonsils, as well as T and B lymphoid cell lines, phosphorylate deoxyguanosine which is probably the major toxic metabolite in purine nucleoside phosphorylase (PNP) deficiency. T and B cells also have similar activities of purine nucleoside phosphorylase. These findings indicate that the selective T cell defect in patients with PNP deficiency is unlikely to be due to a selective 'trapping' of deoxyguanosine by T lymphocytes.
摘要
来自血液和扁桃体的T淋巴细胞和B淋巴细胞，以及T和B淋巴细胞系，会使脱氧鸟苷磷酸化，而脱氧鸟苷可能是嘌呤核苷磷酸化酶（PNP）缺乏症中的主要毒性代谢产物。T细胞和B细胞也具有相似的嘌呤核苷磷酸化酶活性。这些发现表明，PNP缺乏症患者中选择性的T细胞缺陷不太可能是由于T淋巴细胞对脱氧鸟苷的选择性“捕获”所致。
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引用本文的文献
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Biochem J. 1983 Sep 15;214(3):711-8. doi: 10.1042/bj2140711.
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