脱氧鸟苷对小鼠T淋巴瘤的毒性：与嘌呤核苷磷酸化酶相关免疫功能障碍的关系。 - Suppr

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超能文献

Deoxyguanosine toxicity in a mouse T lymphoma: relationship to purine nucleoside phosphorylase-associated immune dysfunction.

作者信息

Gudas L J, Ullman B, Cohen A, Martin D W

出版信息

Cell. 1978 Jul;14(3):531-8. doi: 10.1016/0092-8674(78)90239-8.

DOI:10.1016/0092-8674(78)90239-8

PMID:99243

Abstract

摘要

相似文献

Deoxyguanosine toxicity in a mouse T lymphoma: relationship to purine nucleoside phosphorylase-associated immune dysfunction.脱氧鸟苷对小鼠T淋巴瘤的毒性：与嘌呤核苷磷酸化酶相关免疫功能障碍的关系。

Cell. 1978 Jul;14(3):531-8. doi: 10.1016/0092-8674(78)90239-8.

Mechanisms of 2'-deoxyguanosine toxicity in mouse T-lymphoma cells with purine nucleoside phosphorylase deficiency and resistance to inhibition of ribonucleotide reductase by dGTP.嘌呤核苷磷酸化酶缺乏且对dGTP抑制核糖核苷酸还原酶具有抗性的小鼠T淋巴瘤细胞中2'-脱氧鸟苷毒性的机制

Biochem J. 1990 Jun 15;268(3):725-31. doi: 10.1042/bj2680725.

Isolation and characterization of purine-nucleoside phosphorylase-deficient T-lymphoma cells and secondary mutants with altered ribonucleotide reductase: genetic model for immunodeficiency disease.嘌呤核苷磷酸化酶缺陷型T淋巴瘤细胞及核糖核苷酸还原酶改变的二级突变体的分离与鉴定：免疫缺陷疾病的遗传模型

Proc Natl Acad Sci U S A. 1979 Mar;76(3):1074-8. doi: 10.1073/pnas.76.3.1074.

Enzyme defects and immune dysfunction.酶缺陷与免疫功能障碍。

Nature. 1978 Dec 7;276(5688):559-60. doi: 10.1038/276559a0.

Deoxyguanosine toxicity on lymphoid cells as a cause for immunosuppression in purine nucleoside phosphorylase deficiency.脱氧鸟苷对淋巴细胞的毒性作为嘌呤核苷磷酸化酶缺乏症中免疫抑制的一个原因。

Cell. 1978 Jul;14(3):523-30. doi: 10.1016/0092-8674(78)90238-6.

Phosphorylation of deoxyguanosine by B and T lymphocytes: evidence against selective trapping of deoxyguanosine by T lymphocytes in purine nucleoside phosphorylase deficiency.B淋巴细胞和T淋巴细胞对脱氧鸟苷的磷酸化作用：嘌呤核苷磷酸化酶缺乏时T淋巴细胞选择性捕获脱氧鸟苷的反证。

Clin Exp Immunol. 1980 Dec;42(3):523-9.

The metabolism of deoxyguanosine and guanosine in human B and T lymphoblasts. A role for deoxyguanosine kinase activity in the selective T-cell defect associated with purine nucleoside phosphorylase deficiency.人B淋巴细胞和T淋巴细胞中脱氧鸟苷和鸟苷的代谢。脱氧鸟苷激酶活性在与嘌呤核苷磷酸化酶缺乏相关的选择性T细胞缺陷中的作用。

Biochem J. 1983 Sep 15;214(3):711-8. doi: 10.1042/bj2140711.

Deoxyguanosine triphosphate as a possible toxic metabolite in the immunodeficiency associated with purine nucleoside phosphorylase deficiency.三磷酸脱氧鸟苷作为与嘌呤核苷磷酸化酶缺乏相关免疫缺陷中一种可能的毒性代谢产物。

J Clin Invest. 1978 May;61(5):1405-9. doi: 10.1172/JCI109058.

Urinary purines in a patient with a severely defective T cell immunity and a purine nucleoside phosphorylase deficiency.一名T细胞免疫严重缺陷且患有嘌呤核苷磷酸化酶缺乏症患者的尿嘌呤情况。

Adv Exp Med Biol. 1977;76A:471-6. doi: 10.1007/978-1-4613-4223-6_59.

[Primary immunodeficiencies and purine metabolism].[原发性免疫缺陷与嘌呤代谢]

Rev Clin Esp. 1985 Oct;177(6):247-53.

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Mitochondrial basis for immune deficiency. Evidence from purine nucleoside phosphorylase-deficient mice.免疫缺陷的线粒体基础。来自嘌呤核苷磷酸化酶缺陷小鼠的证据。

J Exp Med. 2000 Jun 19;191(12):2197-208. doi: 10.1084/jem.191.12.2197.

Cloning of human purine-nucleoside phosphorylase cDNA sequences by complementation in Escherichia coli.通过在大肠杆菌中互补克隆人嘌呤核苷磷酸化酶cDNA序列。

Proc Natl Acad Sci U S A. 1983 Jul;80(14):4281-5. doi: 10.1073/pnas.80.14.4281.

Regulation of ribonucleotide reductase activity in mammalian cells.哺乳动物细胞中核糖核苷酸还原酶活性的调控。

Mol Cell Biochem. 1983;53-54(1-2):257-66. doi: 10.1007/BF00225258.

2'-deoxyguanosine toxicity for B and mature T lymphoid cell lines is mediated by guanine ribonucleotide accumulation.2'-脱氧鸟苷对B淋巴细胞系和成熟T淋巴细胞系的毒性是由鸟嘌呤核糖核苷酸积累介导的。

J Clin Invest. 1984 Nov;74(5):1640-8. doi: 10.1172/JCI111580.

Specific cytotoxicity of arabinosylguanine toward cultured T lymphoblasts.阿糖基鸟嘌呤对培养的T淋巴母细胞的特异性细胞毒性。

J Clin Invest. 1984 Sep;74(3):951-5. doi: 10.1172/JCI111514.

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