Wildt L, Hausler A, Hutchison J S, Marshall G, Knobil E
Endocrinology. 1981 May;108(5):2011-3. doi: 10.1210/endo-108-5-2011.
The temporal relationship between cessation of GnRH delivery to the pituitary gland and the loss of responsiveness to the stimulatory action of estradiol (E2) was examined in 4 ovariectomized rhesus monkeys whose endogenous GnRH production had been abolished by hypothalamic lesions. Gonadotropin secretion was re-established by the intermittent administration of GnRH. The GnRH-replacement regimen was then discontinued and estradiol benzoate (EB) injected 24, 48, 72 and 96 hours later. Unambiguous gonadotropin discharges were induced when EB was administered 24 or 48 hours after discontinuation of GnRH replacement. We conclude that E2 can initiate gonadotropin discharges in the absence of circulating GnRH. E2 may, therefore, be viewed as a gonadotropin releasing hormone.
在4只卵巢切除的恒河猴中研究了向垂体输送促性腺激素释放激素（GnRH）停止与丧失对雌二醇（E2）刺激作用反应之间的时间关系，这些猴子的内源性GnRH分泌已因下丘脑损伤而被消除。通过间歇性给予GnRH使促性腺激素分泌得以重建。然后停止GnRH替代方案，并在24、48、72和96小时后注射苯甲酸雌二醇（EB）。在停止GnRH替代24或48小时后给予EB时，可诱导明确的促性腺激素释放。我们得出结论，在没有循环GnRH的情况下，E2可引发促性腺激素释放。因此，E2可被视为一种促性腺激素释放激素。
