Grundy E M, Ramamurthy S, Patel K P, Mani M, Winnie A P
Br J Anaesth. 1978 Aug;50(8):805-9. doi: 10.1093/bja/50.8.805.
The results of 334 lumbar extradural analgesics, administered in a standard manner, allowed reassessment of some factors influencing the spread of local anaesthetic solution in the extradural space. There was no evidence of increased spread in patients with degenerative vascular disease when compared with a control group free from such disease. The patient's height and age had a small effect on spread. The results contradict the earlier assumption of a direct relationship between the volume of anaesthetic solution injected and the number of segments blocked.
以标准方式给予334例腰椎硬膜外镇痛剂的结果，使得对一些影响局部麻醉溶液在硬膜外腔扩散的因素能够进行重新评估。与无此类疾病的对照组相比，患有退行性血管疾病的患者没有扩散增加的证据。患者的身高和年龄对扩散有微小影响。这些结果与早期关于注入麻醉溶液的体积与阻滞节段数量之间存在直接关系的假设相矛盾。
