Gamma-butyrolactone-gamma-carbonyl-histidyl-prolinamide citrate (DN-1417): a novel TRH analog with potent effects on the central nervous system.

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作者信息

Miyamoto M, Fukuda N, Narumi S, Nagai Y, Saji Y, Nagawa Y

出版信息

Life Sci. 1981 Feb 23;28(8):861-9. doi: 10.1016/0024-3205(81)90047-3.

DOI:10.1016/0024-3205(81)90047-3

PMID:6783804

Abstract

摘要

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Gamma-butyrolactone-gamma-carbonyl-histidyl-prolinamide citrate (DN-1417): a novel TRH analog with potent effects on the central nervous system.

Life Sci. 1981 Feb 23;28(8):861-9. doi: 10.1016/0024-3205(81)90047-3.

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[A TRH analog (DN-1417). Antagonistic effects on reserpine-induced decreases in local cerebral glucose utilization and cerebral monoamine levels].[一种促甲状腺激素释放激素类似物（DN - 1417）。对利血平诱导的局部脑葡萄糖利用和脑单胺水平降低的拮抗作用]

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[TRH and its analog (DN-1417). Effects on central dopaminergic system-dependent behaviors in rats and mice].[促甲状腺激素释放激素及其类似物（DN - 1417）。对大鼠和小鼠中枢多巴胺能系统依赖性行为的影响]

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引用本文的文献

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Distribution and characterization of the TRH receptors in the CNS of ataxic mutant mouse.共济失调突变小鼠中枢神经系统中促甲状腺激素释放激素受体的分布与特性

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Intracerebroventricular injection of a TRH analogue, gamma-butyrolactone-gamma-carbonyl-L-histidyl-prolinamide, induces gastric lesions and gastric acid stimulation in rats.向大鼠脑室内注射促甲状腺激素释放激素类似物γ-丁内酯-γ-羰基-L-组氨酰-脯氨酰胺，会诱发胃部损伤并刺激胃酸分泌。

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Effects of a new TRH analogue, YM-14673 on a passive avoidance test as a possible criterion of improvement in cognitive disturbance in rodents.新型促甲状腺激素释放激素类似物YM-14673对被动回避试验的影响，作为啮齿动物认知障碍改善的可能标准。

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Antagonizing effects of YM-14673, a new TRH derivative, on behavioral and electroencephalographic changes in reserpinized animals.新型促甲状腺激素释放激素衍生物YM-14673对利血平化动物行为和脑电图变化的拮抗作用

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Effects of a new TRH analogue, YM-14673 on the central nervous system.

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Comparative effects of thyrotropin releasing hormone, MK-771 and DN-1417 on morphine abstinence syndrome.促甲状腺激素释放激素、MK-771和DN-1417对吗啡戒断综合征的比较作用。

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