Yamaguchi T, Hayashi K, Murakami H, Maruyama S, Yamaguchi M
Neurochem Res. 1984 Apr;9(4):477-84. doi: 10.1007/BF00964374.
The distribution of TRH receptors in the membrane fraction of the CNS in ataxic mutant mice (C3Hf/Nem-rol and C57BL/6j-tg) was studied. TRH binding sites in cerebellum and frontal lobe of the ataxic form and the non-ataxic heterozygotes of Rolling Mouse Nagoya were decreased in comparison with the controls, whereas those in the spinal cord of Rolling Mouse Nagoya and cerebellum of Tottering Mouse were increased in the ataxic mice over the controls. Kinetic studies were performed on cerebrum and cerebellum of the different ataxic mutant mice. Such species differences in the distribution of the TRH receptors have to be considered in the action of TRH in individual ataxia cases.
研究了共济失调突变小鼠（C3Hf/Nem-rol和C57BL/6j-tg）中枢神经系统膜部分中促甲状腺激素释放激素（TRH）受体的分布。与对照组相比，名古屋滚动小鼠共济失调型及其非共济失调杂合子的小脑和额叶中的TRH结合位点减少，而名古屋滚动小鼠脊髓和蹒跚小鼠小脑中的TRH结合位点在共济失调小鼠中比对照组增加。对不同共济失调突变小鼠的大脑和小脑进行了动力学研究。在个别共济失调病例中，TRH发挥作用时必须考虑TRH受体分布的这种物种差异。
