Sauer R
Strahlentherapie. 1981 Feb;157(2):71-80.
Many experiences with breast-saving primary radiation therapy following tumorectomy justify the utilization of this method as an alternative to mastectomy. Complications are insignificant, cosmetic results excellent in general, on the condition, however, of rigorous indication, of careful and atraumatic surgical technique and of exactly planned and accurately delivered megavoltage therapy. Local and regional tumor control amounts to 90% in Stage-I cases, to 85% in Stage II, and to about 65% in Stage III. Five-year survival is obtained in 85 to 95% of Stage I cases, in 65 to 75% of Stage II and in about 25% of Stage III cases. Ten-year survival rate lies between 45 and 60%. No sign of secondary malignomas possibly induced by curative radiation therapy has been found till now.
肿瘤切除术后进行保乳原发性放射治疗的诸多经验证明，将该方法作为乳房切除术的替代方案是合理的。并发症并不严重，总体美容效果极佳，但条件是要有严格的适应症、细致且无创的手术技术以及精确规划和准确实施的兆伏级治疗。I期病例的局部和区域肿瘤控制率达90%，II期为85%，III期约为65%。I期病例的五年生存率为85%至95%，II期为65%至75%，III期约为25%。十年生存率在45%至60%之间。到目前为止，尚未发现由根治性放射治疗可能诱发的继发性恶性肿瘤迹象。
