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mus(3)312D1，一种对黑腹果蝇雌性减数分裂有深远影响的诱变敏感突变体。

mus(3)312D1, A mutagen sensitive mutant with profound effects on female meiosis in Drosophila melanogaster.

作者信息

Green M M

出版信息

Chromosoma. 1981;82(2):259-66. doi: 10.1007/BF00286110.

DOI:10.1007/BF00286110
PMID:6785045
Abstract

The third chromosome, mutagen sensitive mutant mus(3)312D1 impairs the meiotic process in females by increasing the frequency of first division nondisjunction and decreasing the frequency of meiotic crossing over. These genetic properties connote 312 to be defective in DNA replication and/or repair intimately associated with the crossing over exchange process. The mutant maps to the left arm of chromosome III between ru and h, and represents a new genetic site for a meiotic mutant.

摘要

第三条染色体上的诱变敏感突变体mus(3)312D1通过增加第一次分裂不分离的频率和降低减数分裂交换的频率来损害雌性的减数分裂过程。这些遗传特性表明312在与交换过程密切相关的DNA复制和/或修复方面存在缺陷。该突变体定位于第三条染色体左臂ru和h之间，代表了一个减数分裂突变体的新遗传位点。

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本文引用的文献

1
Effects of recombination-deficient and repair-deficient loci on meiotic and mitotic chromosome behavior in Drosophila melanogaster.重组缺陷和修复缺陷基因座对黑腹果蝇减数分裂和有丝分裂染色体行为的影响。
Basic Life Sci. 1980;15:189-208. doi: 10.1007/978-1-4684-3842-0_13.
2
Isolation and characterization of repair-deficient mutants of Drosophila melanogaster.
Basic Life Sci. 1980;15:175-88. doi: 10.1007/978-1-4684-3842-0_12.
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Biochemical characterization of repair-deficient mutants of Drosophila.果蝇修复缺陷型突变体的生化特性
PLoS Genet. 2011 Oct;7(10):e1002315. doi: 10.1371/journal.pgen.1002315. Epub 2011 Oct 13.
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Chromosoma. 2011 Apr;120(2):109-27. doi: 10.1007/s00412-010-0304-7. Epub 2011 Jan 11.
5
Drosophila MUS312 and the vertebrate ortholog BTBD12 interact with DNA structure-specific endonucleases in DNA repair and recombination.果蝇MUS312和脊椎动物直系同源基因BTBD12在DNA修复和重组过程中与DNA结构特异性核酸内切酶相互作用。
Mol Cell. 2009 Jul 10;35(1):128-35. doi: 10.1016/j.molcel.2009.06.019.
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An essential role of DmRad51/SpnA in DNA repair and meiotic checkpoint control.DmRad51/SpnA在DNA修复和减数分裂检查点控制中的重要作用。
EMBO J. 2003 Nov 3;22(21):5863-74. doi: 10.1093/emboj/cdg564.
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Drosophila MUS312 interacts with the nucleotide excision repair endonuclease MEI-9 to generate meiotic crossovers.果蝇MUS312与核苷酸切除修复内切核酸酶MEI-9相互作用以产生减数分裂交叉。
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Genetics. 1996 Sep;144(1):215-28. doi: 10.1093/genetics/144.1.215.
9
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