Chen C, Jones W R
Fertil Steril. 1981 May;35(5):542-5. doi: 10.1016/s0015-0282(16)45497-x.
A complement-dependent sperm micro-immobilization test for antisperm antibodies in cervical mucus was evaluated in 195 infertile women. Positive tests were obtained among 17% of women with "unexplained" and 12% with an "organic" basis for their infertility. The results confirmed previous reports of the presence of cervical mucus antibodies in the absence of corresponding activity in serum. Non-complement-dependent sperm-immobilizing activity was also detected in the cervical mucus of several patients. During a follow-up period of 9 to 24 months, 10% of those with "unexplained" infertility who had complement-dependent sperm-immobilizing antibodies in their mucus became pregnant, compared with 29% of those without antibodies. The corresponding pregnancy rates for patients with "'organic" infertility were 18% and 11%. In four patients with positive tests who subsequently conceived, further tests failed to detect the persistence of the immobilizing activity.
对195名不孕女性进行了一项用于检测宫颈黏液中抗精子抗体的补体依赖型精子微固定试验。在17% “不明原因” 的不孕女性和12% 有 “器质性” 不孕原因的女性中检测到阳性结果。结果证实了先前的报道，即在血清中没有相应活性的情况下，宫颈黏液中存在抗体。在几名患者的宫颈黏液中还检测到了非补体依赖型精子固定活性。在9至24个月的随访期内，黏液中存在补体依赖型精子固定抗体的 “不明原因” 不孕患者中有10% 怀孕，而无抗体的患者中这一比例为29%。“器质性” 不孕患者的相应妊娠率分别为18% 和11%。在4名检测呈阳性且随后怀孕的患者中，进一步检测未能发现固定活性的持续存在。
