Tsuboi K K, Thompson D J, Rush E M, Schwartz H C
Hemoglobin. 1981;5(3):241-50. doi: 10.3109/03630268108997548.
In the presence of acetaldehyde, metabolizing human erythrocytes accumulate an altered hemoglobin product showing chromatographic similarity to hemoglobin AIa or AIb. The adduct is stable to overnight dialysis with an intracellular half-life of about 5.5 days. Adduct formation is accompanied by proportional changes in cell oxygen affinity (decrease in P50 of 3 mm Hg/mM adduct). Little unaltered hemoglobin remains after overnight incubation in 15 mM acetaldehyde, with significant adduct formation and marked reduction of cell ATP occurring after prolonged incubation in as little as 0.5 mM acetaldehyde.
在乙醛存在的情况下，正在进行代谢的人体红细胞会积累一种改变后的血红蛋白产物，该产物在色谱上与血红蛋白AIa或AIb相似。这种加合物对过夜透析稳定，细胞内半衰期约为5.5天。加合物的形成伴随着细胞氧亲和力的成比例变化（每毫摩尔加合物P50降低3毫米汞柱）。在15毫摩尔乙醛中过夜孵育后，几乎没有未改变的血红蛋白残留，在低至0.5毫摩尔乙醛中长时间孵育后会有显著的加合物形成和细胞ATP的明显减少。
