Bogatskaia L N, Korkushko O V, Pisaruk A V
Ukr Biokhim Zh (1978). 1986 Mar-Apr;58(2):41-5.
The glycolysis rate and the amount of the acid-transport hemoglobin function modulators (diphosphoglycerate (2,3-DPG), ATP, glutathione, chlorides) in human erythrocytes are studied under the effect of age changes. It is shown that the glycolysis rate and the content of ATP decrease under ageing by 16% and 21%, respectively. The concentration of 2,3-DPG lowers insignificantly (by 8%). At the same time it is established that the amount of reduced glutathione in erythrocytes of middle-aged and old people enhances by 25-29% and that of chlorine ions by 23-24%. The revealed changes in the concentration of modulators of the hemoglobin affinity to oxygen with ageing are, probably, one of reasons of the oxyhemoglobin dissociation increase.
在年龄变化的影响下，研究了人体红细胞中的糖酵解速率以及酸转运血红蛋白功能调节剂（二磷酸甘油酸（2,3-DPG）、三磷酸腺苷（ATP）、谷胱甘肽、氯化物）的含量。结果表明，随着年龄增长，糖酵解速率和ATP含量分别下降了16%和21%。2,3-DPG的浓度略有降低（8%）。同时发现，中年人和老年人红细胞中还原型谷胱甘肽的含量增加了25%-29%，氯离子的含量增加了23%-24%。随着年龄增长，所揭示的血红蛋白与氧亲和力调节剂浓度的变化可能是氧合血红蛋白解离增加的原因之一。
