Heys D R, Heys R J, Cox C F, Avery J K
J Oral Pathol. 1980 Nov;9(6):372-9. doi: 10.1111/j.1600-0714.1980.tb00393.x.
Dentinal bridge formation and pulpal responses of four calcium hydroxide materials, pulp capping medicaments, MPC, Experimental MPC-12, Dycal and Pulpdent, were evaluated in primary and permanent monkey teeth. A total of 60 primary and 60 permanent teeth were used with each material placed in a Class V cavity exposure in Rhesus monkey teeth. The materials were placed on the exposed pulp tissue and were histologically evaluated at 3 days, 5 weeks and 8 weeks. After perfusion the teeth were processed using routine histological procedures. The 3-day pulpal responses in both primary and permanent teeth were moderate, characterized by disruption of the pulpal tissue directly beneath the exposure site and a zone of acute inflammation and hemorrhage in the underlying pulp. The 5-week response showed histological differences between the four medicaments, with Dycal producing the least amount of pulpal irritation with reparative dentin bridges occurring in 50% of the permanent teeth. Experimental MPC-12 stimulated one reparative dentin bridge, while Pulpdent and MPC showed no evidence of bridge formation. Pulpal responses to Dycal were moderate and moderate to severe for the other calcium hydroxide compounds. No reparative dentin bridges were seen in the primary teeth at 5 weeks with any of the materials, and the pulpal responses were of a moderate degree at that time. Eight-week responses were similar to the 5-week responses Dycal provoked a slight to moderate pulpal response with 50% success at bridging. Experimental MPC-12 initiated pulpal responses in the moderate to severe range with some bridging evident. Pulpdent incited moderate to severe histological responses with three teeth demonstrating bridge formation, and MPC provoked severe pulpal responses with no bridging. Primary teeth showed some bridging for all compounds except those treated with MPC, in which no evidence of bridging occurred, and moderate to severe pulpal responses were present.
在恒河猴的乳牙和恒牙中，评估了四种氢氧化钙材料（盖髓剂）——MPC、实验性MPC-12、Dycal和Pulpdent的牙本质桥形成及牙髓反应。总共使用了60颗乳牙和60颗恒牙，每种材料放置于恒河猴牙齿的V类洞穿髓处。将材料放置在暴露的牙髓组织上，并在3天、5周和8周时进行组织学评估。灌注后，牙齿采用常规组织学方法处理。乳牙和恒牙在3天时的牙髓反应均为中度，其特征是暴露部位正下方的牙髓组织破坏以及下方牙髓出现急性炎症和出血区。5周时的反应显示四种药物之间存在组织学差异，Dycal产生的牙髓刺激最少，50%的恒牙出现修复性牙本质桥。实验性MPC-12刺激形成了一个修复性牙本质桥，而Pulpdent和MPC未显示桥形成的迹象。Dycal的牙髓反应为中度，其他氢氧化钙化合物的牙髓反应为中度至重度。5周时，任何材料处理的乳牙均未见到修复性牙本质桥，此时牙髓反应为中度。8周时的反应与5周时相似，Dycal引起轻微至中度的牙髓反应，桥接成功率为50%。实验性MPC-12引发中度至重度的牙髓反应，有一些桥接明显。Pulpdent引发中度至重度的组织学反应，三颗牙齿显示有桥形成，MPC引发严重的牙髓反应且无桥接。除用MPC处理的乳牙外，所有化合物处理的乳牙均有一些桥接，MPC处理的乳牙未出现桥接迹象，但有中度至重度的牙髓反应。
