Heys D R, Heys R J, Cox C F, Avery J K
J Oral Pathol. 1976 May;5(3):129-48. doi: 10.1111/j.1600-0714.1976.tb01759.x.
Pulpal response of four calcium hydroxide liners, MPC 10, MPC 12, Dycal and Pulpdent were tested on primary and permanent teeth with zinc oxide and eugenol (ZOE) and silicate as controls. Responses of the pulps were evaluatedi in Rhesus monkeys, utilizing Class V cavity preparations at 3 days, 5 and 8 weeks. An equivalent number of anterior and posterior teeth were studied for all compounds. The Ca(OH)2 liners, zinc oxide and eugenol (ZOE) and silicate controls were placed in 80 primary and 80 permanent teeth. Following perfusions the teeth were prepared utilizing routine histological procedures. The 3 day response of the calcium hydroxides was moderate with some disruption in the odontoblasts, vacuolization and mild inflammation underlying the cavity except Pulpdent which was more severe. At 5 weeks a decrease in inflammatory response and the formation of reparative dentin was similar for all calcium hydroxides tested at this time period. At 8 weeks more reparative dentin was noted with slight to moderate pulpal responses. At all time periods ZOE produced the least pulpal response while silicate produced the most severe response at 5 and 8 weeks. This study reports the biological responses of four calcium hydroxide compounds used as cavity liners in non-exposures in a series of primary and permanent teeth of monkeys using ZOE and silicate as controls. Responses to the four Ca(OH)2 compounds were moderate for all the experimental compounds except Pulpdent which was more severe at the early time period tested. ZOE produced a milder and silicate a severe response at all periods. All of these compounds were placed by random selection in anterior and posterior teeth of both arches and five teeth were evaluated in both primary and permanent teeth at 3 days, 5 and 8 weeks.
以氧化锌丁香酚（ZOE）和硅酸盐作为对照，在恒河猴的乳牙和恒牙上测试了四种氢氧化钙垫底材料（MPC 10、MPC 12、Dycal和Pulpdent）的牙髓反应。在3天、5周和8周时，利用V类洞型制备，在恒河猴中评估牙髓反应。对所有化合物，研究了等量的前牙和后牙。将氢氧化钙垫底材料、氧化锌丁香酚（ZOE）和硅酸盐对照物分别置于80颗乳牙和80颗恒牙中。灌注后，按照常规组织学程序制备牙齿。除Pulpdent的反应更严重外，氢氧化钙材料在3天时的反应为中度，成牙本质细胞有一些破坏，洞底有液泡形成和轻度炎症。在5周时，所有测试的氢氧化钙材料在这个时间段的炎症反应均有所减轻，且有修复性牙本质形成。在8周时，观察到更多的修复性牙本质，牙髓反应为轻度至中度。在所有时间段，ZOE产生的牙髓反应最小，而硅酸盐在5周和8周时产生的反应最严重。本研究报告了在一系列猴乳牙和恒牙非露髓情况下，以ZOE和硅酸盐作为对照，四种用作洞衬的氢氧化钙化合物的生物学反应。除Pulpdent在测试早期反应更严重外，所有实验化合物对四种氢氧化钙化合物的反应均为中度。在所有时间段，ZOE产生的反应较轻微，而硅酸盐产生的反应较严重。所有这些化合物均随机放置在上下颌的前牙和后牙中，在3天、5周和8周时，对乳牙和恒牙中的五颗牙齿进行评估。
