Chatfield D H, Woodage T J
Biomed Mass Spectrom. 1978 Jul;5(7):466-8. doi: 10.1002/bms.1200050709.
A selected ion monitoring method for the estimation of an anti-allergy compound isamaxole (N-butyl-N-(4-methyloxazol-2-yl)-2-methylpropanamide, LRCL 3950) in plasma has been developed. The method uses a stable analogue containing nine deuterium atoms as internal standard. The assay is sensitive to 2 ng ml-1 plasma and has been used to examine plasma levels of isamoxole after doses of the compound to animals and man.
已开发出一种用于测定血浆中抗过敏化合物伊沙莫唑（N-丁基-N-(4-甲基恶唑-2-基)-2-甲基丙酰胺，LRCL 3950）的选择离子监测方法。该方法使用一种含有九个氘原子的稳定类似物作为内标。该测定法对血浆中2 ng/ml的伊沙莫唑敏感，并已用于检测给动物和人类施用该化合物后的血浆伊沙莫唑水平。
