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采用选择离子监测法对人血浆中的硝苯地平进行定量测定。

Quantitative determination of nifedipine in human plasma by selected ion monitoring.

作者信息

Higuchi S, Shiobara Y

出版信息

Biomed Mass Spectrom. 1978 Mar;5(3):220-3. doi: 10.1002/bms.1200050310.

DOI:10.1002/bms.1200050310
PMID:630063
Abstract

A highly sensitive and specific method for the determination of nifedipine in plasma is described. Nifedipine was oxidized to its pyridine analogue with nitrous acid and determined by selected ion monitoring. Deuterium labeled nifedipine was used as an internal standard. Plasma levels as low as 5 ng ml-1 were measured. The usefulness of the method was demonstrated by obtaining plasma concentration curves for humans after an oral dose of 10 mg.

摘要

本文描述了一种测定血浆中硝苯地平的高灵敏度和特异性方法。硝苯地平用亚硝酸氧化成其吡啶类似物，并用选择离子监测法进行测定。氘标记的硝苯地平用作内标。可测定低至5 ng/ml的血浆水平。通过口服10 mg剂量后获得人体血浆浓度曲线，证明了该方法的实用性。

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Relationship between the antihypertensive effect and steady-state plasma concentration of nifedipine given alone or in combination with a beta-adrenoceptor blocking agent.
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