Delaye J, Foulon P, Chassignolle J, Mikaeloff P, Nantu X, Convert G, Biron A, Gonin A
Arch Mal Coeur Vaiss. 1981 Apr;74(4):409-18.
The improvement in the expectation and quality of life of patients undergoing coronary bypass surgery has been studied in the short term but there are relatively few studies with follow-up periods of over five years. The results in 239 patients operated on between 1970 and 1976 are presented. The preoperative data was obtained from a computerised filing system; studies were made at 3 months, at an average of 60 months, and in 78 patients with follow-up exceeding 5 years. Actuarial survival rates were calculated. The operative mortality was 9 patients (3,7%); late mortality was 21 patients (9,2%). Most deaths were due to cardiac causes. The following factors did not appear to be associated with a poor prognosis: sex, the number of cardiovascular risk factors, the number of bypass grafts; however, age and poor left ventricular function as identified by ECG (p less than 0,01), the presence of clinical cardiac failure (p less than 0,001) and by angiography (p less than 0,001) were associated with a poor prognosis. The long-term functional results were interesting: 67% patients followed up to 5 years and 56% patients followed up for over 5 years had no angina. Myocardial infarction occurred in 16,7% of patients at 5 years. Preexisting left ventricular failure which affected the operative and immediate postoperative results was also found secondarily in 9% of patients at 5 years. In the long term, the annual mortality rate seemed to be less in patients with triple vessel disease after myocardial revascularisation. The annual mortality rate of patients with left anterior descending disease alone did not seem to be improved when compared with medically treated patients until after the third year. Once again, the extent of myocardial disease was shown to be the essential prognostic factor whatever the coronary profile of the patient. In this study patients with severe angina or unstable angina who had been treated medically before surgery had the same results as those treated surgically by first intention; this fact is an argument in favour of initial medical management in all forms of angina.
冠状动脉搭桥手术患者预期寿命和生活质量的改善情况在短期内已有研究,但随访期超过五年的研究相对较少。本文呈现了1970年至1976年间接受手术的239例患者的结果。术前数据来自计算机存档系统;分别在术后3个月、平均60个月时进行研究,并对78例随访期超过5年的患者进行了研究。计算了精算生存率。手术死亡率为9例患者(3.7%);晚期死亡率为21例患者(9.2%)。大多数死亡是由心脏原因导致的。以下因素似乎与预后不良无关:性别、心血管危险因素数量、搭桥血管数量;然而,年龄以及心电图显示的左心室功能不佳(p<0.01)、临床心力衰竭的存在(p<0.001)以及血管造影显示的情况(p<0.001)与预后不良相关。长期功能结果令人关注:随访至5年的患者中有67%、随访超过5年的患者中有56%无心绞痛。5年时16.7%的患者发生心肌梗死。术前存在的左心室衰竭影响了手术及术后即刻结果,5年时在9%的患者中再次出现。从长期来看,心肌血运重建术后三支血管病变患者的年死亡率似乎较低。单纯左前降支病变患者的年死亡率与药物治疗患者相比,直到第三年似乎都没有改善。再次表明,无论患者的冠状动脉情况如何,心肌病变程度都是关键的预后因素。在本研究中,术前接受药物治疗的严重心绞痛或不稳定心绞痛患者与直接接受手术治疗的患者结果相同;这一事实支持了对所有类型心绞痛进行初始药物治疗的观点。